Make your own free website on

Retinitis Pigmentosa

Contact Me

About My Mom
Retinitis Pigmentosa Foundation
Retinitis Pigmentosa Treatment
Retinitis Pigmentosa Cure
Retinitis Pigmentosa Research
Books About Eyesight
Family Photo Album
Contact Me

Do you have a similar story? Do you have advice for me? Please get in touch! Just click this address to send me mail:

More info on Retinitis Pigmentosa

Retinitis Pigmentosa

Retinitis Pigmentosa, or RP, is a genetic eye condition. Generally, night blindness precedes tunnel vision by years or even decades. Many people with RP don't become legally blind until their 40s and 50s and retain some sight all their life. Other's go completely blind from RP, in some cases as early as childhood. Progression of RP is different in each case.

RP is a group of inherited disorders in which abnormalities of the photoreceptors (rods and cones) or the retinal pigment epithelium (RPE) of the retina lead to progressive visual loss. Affected individuals first experience defective dark adaptation or "night blindness," followed by constriction of the peripheral visual field and, eventually, loss of central vision late in the course of the disease.

The diagnosis of RP relies upon documentation of progressive loss in photoreceptor function by electroretinography (ERG) and visual field testing. The mode of inheritance of RP is determined by family history. At least 35 different genes or loci are known to cause nonsyndromic RP. DNA testing is available on a clinical basis for RLBP1 (autosomal recessive, Bothnia type RP), RP1 (autosomal dominant, RP1), RHO (autosomal dominant, RP4), RDS (autosomal dominant, RP7), PRPF8 (autosomal dominant, RP13), PRPF3 (autosomal dominant, RP18), CRB1 (autosomal recessive, RP12), ABCA4 (autosomal recessive, RP19), and RPE65 (autosomal recessive, RP20). For all other genes, molecular genetic testing is available on a research basis only.

RP can be inherited in an autosomal dominant, autosomal recessive, or X-linked manner. X-linked RP can be either recessive, affecting primarily only males, or dominant, affecting both males and females, although females are always more mildly affected. Some digenic and mitochondrial forms have also been described. Genetic counseling depends on an accurate diagnosis, determination of the mode of inheritance in each family, and results of molecular genetic testing. RP combined with progressive deafness is called Usher syndrome.

There is currently no medical treatment for Retinitis Pigmentosa.

Scientists continue to investigate possible treatments for RP. Future treatments may involve retinal implants, stem cells, gene therapy, retinal transplants, nutritional supplements, and/or drug therapies.

Retinitis Pigmentosa